5965–5973.INTO THE CALORIMETRIC CELL. THE CHANGE IN THERMAL POWER...

into the calorimetric cell. The change in thermal power as a

4 Aud D & Peng SL (2006) Mechanisms of disease:

function of each injection was automatically recorded using

transcription factors in inflammatory arthritis. Nat Clin

Microcal

software [39] and the raw data were inte-

Pract Rheumatol

grated to yield ITC isotherms of heat release per injection as

5 Wagner EF & Eferl R (2005) Fos

AP-1 proteins in bone

a function of the Fos to Jun molar ratio. In general, the con-

and the immune system. Immunol Rev

centration of peptide 2 loaded into the cell was 30

the

6 Zenz R, Eferl R, Scheinecker C, Redlich K, Smolen J,

anticipated PPI K

_D

and the concentration of peptide 1 in the

Schonthaler HB, Kenner L, Tschachler E & Wagner EF

syringe was at least 20

the concentration of peptide 2. No

(2008) Activator protein 1 (Fos

Jun) functions in

precipitation of protein was observed in any of the experi-

inflammatory bone and skin disease. Arthritis Res Ther

ments undertaken. Following ITC measurements, the data