12. 13. 14. 15. III. READ THE TEXT BELOW AND COMPLETE ITS SUMM...

11. 12. 13. 14. 15. III. Read the text below and complete its summary with words from word list. (5 points) A buzz in the world of chemistry For the past few years, one of the buzz terms in the technology. Some of the more specialist journalists have pharmaceutical, agrochemical and biotechnology industries even devoted whole issues to reviewing combinatorial has been ‘combinatorial chemistry’. Surf the net and find chemistry. thousands of references to it. Read any of the general These reviews all have the same format. First there is a section from the Research and development director of a science weeklies, such as Nature or New Scientist, and every major chemical company, a person who has not worked at few issues, another worthy author is going to save the 21

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century from everything nasty with this miraculous the bench for years, if not decades. This is filled with business speak, the jargon keeps the shareholders happy and Combinatorial chemistry is a branch of synthetic organic makes them proud to own a bit of something at the forefront chemistry. We all remember mathematics classes at school of scinece. Section two is from a director of a venture capital just before the end of term when we were givne silly sums to funded synthetic chemistry company located on a green field do: How many ways can five dirrerently colored beads be site, probably a portcabin, or, perhaps, in a new business arranged on a string? (120). Maths teachers call these park, rent free for the first five years from the local authority permutation and combination problems, hence, combinatorial chemistry. of a small town no one has heard of. He discusses the molecular modelling packages that they are using to build After the development of solid phase peptide synthesis in the ‘virtual’ libraries containing millions of compounds. The 1960s by Merrifield, soon synthetic peptide chemists were also doing permutation and combination sums. There are 20 third section is by someone who in fact, practises combinatorial chemistr and who has developed automated naturally occuring amino acids, the building blocks of peptides and proteins, the workhouse molecules of life. How systems to do the syntheses and to assay the products. They many ways can these be arranged, or chemically bonded, to can probably synthesise a few thousand compounds per synthesis novel peptides which might be put to any number week. We know that organic chemistry is the chemistry of carbon, of uses in the pharmacy? Proteins contain hundreds of amino acids. The number of possible sequences are truly biochemistry the chemistry of life and physical chemistry the application of physics to chemical behaviou. What then innumerable! is combinatorial chemistry? Word list Doubled Offshoot Know As Follow religiously Limited In vogue Limitless In the air references Appearing Offspring Usually follow Once Until Combinatorial chemistry as an (1)_______ of synthetic organic chemistry has been very much (2)_______ in recent years, (3)_______ in a plethora of articles written by experts in the filed. Moreover, all the reviews in specialist publications(4)_______ the same formula. But what about the origin of combinatorial chemistry? It comes from permutation and combination problems in mathematics. Once solid phase pepetide synthesis was developed, synthetic peptide chemists started doing similar calculations as well. The 20 naturally occurring animo acids provided them with(5)_______ possibilities. Part D. WRITING Rewrite the following sentences using the words given. (10 points)