HAS A NEW HEMATOLOGIC DISORDER BEEN DIAGNOSED

4. Has a new hematologic disorder been diagnosed?

Factors influencing long-term risk include: integration of the vector into

the genome; vector persistence without integration; and transgene-specific effects

Acknowledgment

I would like to thank Valder Arruda, MD, PhD, for his review of the

manuscript

Further Readings

Hacein-Bey-Abina S et al: LMO2-associated clonal T cell proliferation in

two patients after gene therapy for SCID-XI. Science 302:415, 2003 [PMID: