9·105 (3.86·104)THE FORMATION OF A COILED COIL STRUCTURE. FRACTION H...

7. - BÁO CÁO KHOA HỌC: THERMODYNAMIC ANALYSIS OF JUN–FOS COILED COIL PEPTIDE ANTAGONISTS PDF
Khoa học BÁO CÁO KHOA HỌC: THERMODYNAMIC ANALYSIS OF JUN–FOS COILED COIL PEPTIDE ANTAGONISTS PDF
7.9·10

5

(3.86·10

4

)the formation of a coiled coil structure. Fraction helicity (ƒ

H

) canbe calculated as ƒ

H

= (h

222

)h

c

)⁄(h

222¥

)h

c

), where h

222¥

=()44000 + 250T)·(1 –k⁄Nr) and h

c

= 2220 – (53·T). In theseequations the wavelength-dependent constantk= 2.4 (at 222 nm),Nr= the number of residues andT= 20C (293 K). Agadir [34–36]severely underestimates helicity for many of the dimeric pairs,most likely because it does not take into account the interhelical